The paper of authors group: K. Šerstņova, M. Pilmane, Z. Vitenberga-Verza, I. Melderis, Ł. Gontar, M. Kochański, A. Drutowska, G. Maróti, and Beatriz Prieto-Simón. 2022. “Expression of anti-inflammatory markers IL-2, IL-10, TGF-β1, βDEF-2, βDEF-3 and Cathelicidin LL37 in dairy cattle milk with different health status of the udder” has been published in Polish Journal of Veterinary Sciences, 2022, vol. 25, No. 2 (2022), 237–248. Journal IF in 2022 is 0,821
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This study demonstrates a distribution and appearance of the presence of IL-2, IL-10, TGF-β1, βDEF-2, DEF-3, and Cathelicidin LL37 proteins in milk samples from 15 cows of Holstein Friesian breed with different health status (5 healthy, 5 subclinical, and 5 clinical animals). The significant decrease of IL-10, β-def2, and β-def3 expression levels found in the milk of animals with sub- and clinical mastitis, indicates the loss of anti-inflammatory protection of the affected cow’s udder and moves these factors as the possible diagnostic markers for the early phasis of mastitis.
The paper of author group has been published on May/June, 2022: Māra Pilmane, Ksenija Šerstņova, Elizabeta Lohova, Lukasz Gontar, Maksymilian Kochanski, Beatriz Prieto-Simón, Andżelika Drutowska, Hedieh Haji-Hashemi, Gergely Maroti. Stabilie citokīni veselu un ar mastītu slimu govju pienā un to korelācija ar sezonalitāti un mikrobiem (The stable Cytokines in the milk of healthy and mastitis-affected cows and their correlation to the seasonality and microbes), Medicus Bonus. 2022: May-June: 17-21.
The article (in Latvian) describes the complex of practically unchanged in their expression of four cytokines: IL-2, -4, 17A, and TGFbeta1 in the milk of healthy and mastitis-affected cows. Data analysis represents also the correlations of these cytokines to the summer/autumn season and milk microbiological findings. Finally, also visual micrographs of cellular cytokines and a possible explanation for the findings are given.
The paper of author group has been published on March, 17, 2022: Vitenberga-Verza, Zane, Māra Pilmane, Ksenija Šerstņova, Ivars Melderis, Łukasz Gontar, Maksymilian Kochański, Andżelika Drutowska, Gergely Maróti, and Beatriz Prieto-Simón. 2022. Identification of Inflammatory and Regulatory Cytokines IL-1α-, IL-4-, IL-6-, IL-12-, IL-13-, IL-17A-, TNF-α-, and IFN-γ-Producing Cells in the Milk of Dairy Cows with Subclinical and Clinical Mastitis, Pathogens. 11, 3: 372.
The paper of author group has been published on March/April, 2021: Māra Pilmane, Zane Vitenberga-Verza, Ksenija Šerstņova, Lukasz Gontar, Maksymilian Kochanski, Beatriz Prieto-Simón, Gergely Maroti, 2021. Citokīni, pretmikrobu proteīni, piens un govs piena dziedzera iekaisums (Cytokins, antimicrobial proteins, milk and mastitis of the bovine udder), Medicus Bonus. 53, 22-27.
The article (in Latvian) states a broad overview of the factors and their role in the development of inflammation in bovine mastitis. Literature review presents a distinct knowledge about cytokines, antimicrobial peptides and their finding in various tissues and cells under varying conditions of homeostasis – from physiological norm to pathology. Visual examples by microphotographies of morphological findings of studied factors in various tissues and cells are also given.